Francesca M. Spagnoli

Francesca Spagnoli-Profile-Image.JPG

Group Leader

King’s College London (KCL)

Spagnoli Lab


Project Coordinator and PI

KCL will be in charge of the coordination of the project. In addition, my lab will contribute to the analysis of the composition and 3D organization of the developing pancreas and to establishing pancreatic cell source(s) for the bioprinting.

The assembly and functionality of the “Pan3DP bioprinted tissue” will be evaluated in cooperation with all partners.


  • Stem cell biologist

  • Developmental biologist


  • Pancreatic development

  • Morphogenesis

  • Pancreatic lineage programming

  • Reprogramming


[Full PubMed List]

  • ‘Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors’ Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM. Nature Communications. In press. 2018

  • ‘Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.’ Cerda-Esteban N, Naumann H, Ruzittu S, Mah N, Pongrac IM, Cozzitorto C, Hommel A, Andrade-Navarro MA, Bonifacio E, Spagnoli FM. Nature Communications. 2017 8: 14127. doi:10.1038/ncomms14127. PMID: 28193997 [PubMed]

  • In vivo reprogramming for tissue repair: Recent breakthroughs and future challenges.’ Heinrich C, Spagnoli FM* and Berninger B*. Nature Cell Biology. 2015 17(3):204-11. doi: 10.1038/ncb3108.

  • Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.’ Rodríguez-Seguel E, Mah N, Naumann H, Pongrac IM, Cerdá-Esteban N, Fontaine JF, Wang Y, Chen W, Andrade-Navarro MA, Spagnoli FM. Genes & Development. 2013 27(17):1932-46. doi: 10.1101/gad.220244.113.PMID: 24013505 [PubMed]

    ‘Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.’ Petzold KM, Naumann H, Spagnoli FM. Development. 2013 1;140(1):126-35. doi: 10.1242/dev.082701. PMID: 23175628 [PubMed]